A medication cassette uses a slidable cartridge having a series of open top medication receiving cells extending in a length thereof. The cartridge slides in an outer sleeve and includes releasable locking arrangements for maintaining the cartridge in a lock position with the sleeve closing the cells, to a release position allowing the cartridge to slide relative to the sleeve and progressively position the cells beyond the sleeve to allow medication to be removed. Both the cartridge and the sleeve are preferably made of a plastic material. The cartridge is preferably a single piece made by injection molding and the sleeve is made by extrusion.