Samuel C. Wagner,Thomas E. Ichim,Santosh Kesari,Amit N. Patel
申请号：
US15001161
公开号：
US20160206717A1
申请日:
2016.01.19
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Disclosed are compositions of matter, methods, and protocols useful for treatment of cancer through induction of anti-angiogenic immune responses. The invention provides means of differentiating tumor cells directly into endothelial or endothelial-like cells and utilizing said cells as immunogens for the purpose of inducing immunity against blood vessels feeding tumors. In one embodiment glioma cells are cultured under hypoxic conditions in the presence of endothelial-differentiating factors. In another embodiment, PECAM-1 positive cells are derived from a tumor mass or cell line and utilized as an antigenic source to induce immunity towards tumor derived endothelial cells, endothelial-like cells, and tumor vascular channels.
