Devices and methods are provided for facilitating ejection of surgical fasteners from a cartridge. In general, the devices and methods can facilitate complete removal of one or more fasteners from within the cartridge. In an exemplary embodiment, a surgical device can be configured to facilitate disconnection of fasteners from a carrier to which the fasteners are frangibly attached. The surgical device can include a separation feature in the form of a shearing element configured to facilitate separation of the fasteners from the carrier when the fasteners are deployed from a cartridge that has the fasteners and the carrier disposed therein.