By identifying (16) locations of contrast agent response, an intensity-based metric of contrast agent signal is used to control (19) a duration of microbubble destruction (18) with a medical ultrasound scanner (20). Feedback from motion of the transducer (22) may be used to indicate when a user perceives enough destruction. A combination of both an intensity-based metric and transducer (22) motion may be used to control the duration of bursting.