Johannes Petrus Thomas Maria Van Leeuwen;Hermanus Johannes Marco Eijken
发明人:
Johannes Petrus Thomas Maria Van Leeuwen,Hermanus Johannes Marco Eijken
申请号：
US12515202
公开号：
US08987203B2
申请日:
2007.11.16
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to methods for selecting a candidate therapeutic agent for controlling mineralization of an extracellular matrix in a tissue of a subject. The invention further relates to a cell culture mineralization model comprising a culture of an extracellular matrix producing cell under conditions that support extracellular matrix formation and matrix maturation, a test compound, and means and methods for determining in expression levels of genes encoding matrix proteins.
