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ВЕЛИПАРИБ В КОМБИНАЦИИ С ЛУЧЕВОЙ ТЕРАПИЕЙ ВСЕГО МОЗГА ДЛЯ ЛЕЧЕНИЯ МЕТАСТАЗОВ В ГОЛОВНОЙ МОЗГ
专利权人:
ЭББВИ ИНК. (US)
发明人:
ЖИРАНДА Винсент Л. (US)
申请号:
RU2014150506
公开号:
RU2014150506A
申请日:
2013.05.15
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A method for the treatment of brain metastases from small cell lung cancer in a subject comprising administering to the subject an effective amount of 2 - [(2R) -2-metillirrolidin-2-yl] -1H-benzimidazole-4-carboxamide or a pharmaceutically acceptable salt thereof combination with an effective amount of radiation just mozga.2. A method according to claim 1, wherein the amount of 2 -. [(2R) -2-methylpyrrolidin-2-yl] -1H-benzimidazole-4-carboxamide is from about 30 to about 600 mg per sutki.3. A method according to claim 1, wherein the amount of 2 -. [(2R) -2-methylpyrrolidin-2-yl] -1H-benzimidazole-4-carboxamide is from about 60 to about 400 mg per sutki.4. A method according to claim 1, wherein the amount of 2 -. [(2R) -2-methylpyrrolidin-2-yl] -1H-benzimidazole-4-carboxamide is about 100 mg sutki.5. A method according to claim 1, wherein the amount of 2 -. [(2R) -2-methylpyrrolidin-2-yl] -1H-benzimidazole-4-carboxamide is about 400 mg sutki.6. A method according to claim 1, wherein 2 -. [(2R) -2-methylpyrrolidin-2-yl] -1H-benzimidazole-4-carboxamide is administered twice a sutki.7. A method according to Claim. 1, wherein the amount of the whole brain irradiation is cumulative dose of about 20 Gy to about 40 Gr.8. A method according to claim. 7, in which the cumulative dose is about 30 Gr.9. A method according to claim. 8, wherein the cumulative dose delivered fractions of about 3.0 Gy per day to 10 fractions in obschem.10. A method according to claim. 7, in which the cumulative dose is about 37.5 Gr.11. The method of claim. 10 wherein the cumulative dose delivered fractions of about 2.5 Gy once a day at 15 in obschem.12 fractions. A method according to claim. 7, in which the cumulative dose is about 35 Gr.13. The method of claim. 12 wherein the cumulative dose delivered fractions of about 2.5 Gy once a day at 14 in obschem.14 fractions. A method according to claim 1, wherein 2 -. [(2R) -2-methylpyrrolidin-2-yl] -1H-benzimidazole-4-carboxamide is administered prio
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