USO DO PÉPTIDO LL-37 DE CATELICIDINA E SEUS DERIVADOS NO TRATMENTO DE FERIDAS CRÓNICAS

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专利权人:

LIPOPEPTIDE AB

发明人:

ANDERS CARLSSON,MONA ST HLE-BÄCKDAHL,JOHAN HEILBORN,CONNY BOGENTOFT

申请号：

PT04705973

公开号：

PT1589987E

申请日:

2004.01.28

申请国别(地区):

PT

年份:

2014

代理人:

摘要：

Use of the antimicrobial cathelicidin peptide II-37, N-terminal fragments of LL-37 or extended sequences of LL-37 having 1-3 amino acids in the C-terminal end, for stimulating proliferation of epithelial and stromal cells and thereby healing of wounds, such as chronic ulcers. The cytotoxic effect of LL-37 may be reduced by including a bilayer-forming polar lipid, especially a digalactosyldiacylglycerol, in pharmaceutical compositions and growth media comprising LL-37.

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