The United States of America as represented by the Department of Veterans Affairs;Loma Linda University
发明人:
Kin-Hing William Lau,Susan L. Hall,Shin-Tai Chen,Subburaman Mohan,David J. Baylink
申请号：
US14287991
公开号：
US09458215B2
申请日:
2014.05.27
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present disclosure provides compositions and methods for increasing bone growth and/or enhancing wound healing, for example, fracture repair. The disclosure provides recombinant nucleic acids useful for promoting bone growth. For example, the disclosure provides recombinant nucleic acids that encode a fibroblast growth factor-2 (FGF-2) analog. The disclosure also provides vectors and cells incorporating these nucleic acids, as well as FGF-2 analogs encode by them. The disclosure also provides a mouse system of bone marrow transplantation and methods for producing as well as methods for using the system. Methods for inducing division and/or inducing differentiation of a hematopoietic stem cell are also provided, as are methods for enhancing bone growth and/or wound repair (for example, fracture repair).
