A compound having the structural formula (A): ** Formula ** or a pharmaceutically acceptable salt, solvate, hydrate or N-oxide thereof, wherein each R3 is independently selected from halo, cyano, - (C1- fluoroalkyl) C4), -O- (C1-C4 fluoroalkyl), acyl, carboxylate, carboxamide and nitro； w is 0, 1 or 2； Q is -CH2-, a single bond, -C (O) - or -CH (CH3) -； the ring system indicated by "A" is phenyl or monocyclic heteroaryl； each R5 is independently selected from - (C1-C6 alkyl), - (C1-C6 fluoroalkyl), - (C0-C6 alkyl) -L-R7, - (C0-C6 alkyl) -NR8R9, - (C0-C6 alkyl ) -OR10, - (C0-C6 alkyl) -S (O) 0-2R10, -halogen, -NO2 and -CN； y is 0, 1, 2, 3 or 4； G is a single bond, -CH2- or -C (O) -； and R17 is aryl or heteroaryl, each optionally substituted, in which each L is independently selected from -NR9C (O) O-, -NR9C (O) -NR9-, -NR9C (O) S-, -NR9C (O ) -, - NR9C (S) O-, -NR9C (S) -NR9-, -NR9C (S) S-, -NR9C (S) -, -OC (O) NR9-, -SC (O) NR9- , -C (S) NR9-, -OC (S) NR9-, - SC (S) NR9-, -C (S) NR9-, -S (O) 0-2-, -C (O) O, -OC (O) -, -C (S) O-, -OC (S) -, -C (O) S-, -SC (O) -, -C (S) S-, -SC (S) -, - OC (O) O-, -SC (O) O-, -OC (O) S-, -SC (S) O-, -OC (S) S-, -NR9C (NR2) NR9-, -NR9SO2-, -SO2NR9- and -NR9SO2NR9-, each R7, R8 and R10 is independently selected from H, - (C1-C6 alkyl), - (C1-C6 fluoroalkyl), - (C0-C6 alkyl) -L- (C0-C6 alkyl), - (C0-C6 alkyl) -NR9 (C0-C6 alkyl), - (C0-C6 alkyl) -O- (C0-C6 alkyl) and - (C0-C6 alkyl) - S ( O) 0-2- (C0-C6 alkyl), each R9 is independently selected from -H, - (C1-C4 alkyl) and -C (O) - (C1-C4 alkyl), optional substituents on atoms of R17 carbon between -R60, halo, -O-M +, -OR70, -SR70, - S-M +, -NR80R80, trihalomethyl, -CF3, -CN, -OCN, -SCN, -NO, -NO2, -N3 , -SO2R70, -SO3 -M +, -SO3R70, -OSO2R70, -OSO3 -M +, -OSO3R70, -PO3 -2 (M +) 2, -P (O) (OR70) O-M +, -P (O) (OR70) ) 2, -C (O) R70, -C (S) R70, -C (NR70) R70, -CO2 -M +, -CO2R70, -C (S) OR70, -C (O) NR80R80, -C (NR70 ) NR80R80, -OC (O) R70, -OC (S) R70, -OCO2 -M +, -OCO2R70, - OC (S) OR70,
