Jerome I. Rotter;Stephan R. Targan;Marla C. Dubinsky;Dermot P. McGovern
发明人:
Marla C. Dubinsky,Dermot P. McGovern,Jerome I. Rotter,Stephan R. Targan
申请号：
US13372359
公开号：
US20120208900A1
申请日:
2012.02.13
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to methods of predicting susceptibility to a severe form of Crohn's disease in an individual by determining the presence or absence of one or more risk variants. In one embodiment, the risk variants comprise a combination of genetic risk variants and clinical risk factors. In another embodiment, the genetic risk variants are at the IL12B genetic locus. In another embodiment, the severe form of Crohn's disease is characterized by a rapid progression to a condition requiring surgery for treatment.
