An enzyme sensor is configured to measure a measurement target substance included in a secretion of a living body. The enzyme sensor includes a layered structure including (a) an absorber layer configured to absorb the secretion, (b) an enzyme layer containing an enzyme, and (c) an electrode part arranged in an order of the (a), the (b), and the (c). The absorber layer includes a polymeric material having a chemically bound crosslinked structure.