A tissue closure device includes a collapsible plug and an actuator. The plug has a surface extending between a proximal face and an opposing distal face. A lumen extends through the plug between the proximal and distal faces along a longitudinal axis. The plug is collapsible between a non-collapsed state in which the lumen is open and a collapsed state in which the lumen is closed. The actuator is configured to move the plug between the non-collapsed state and the collapsed state by being pulled proximally, such as through the lumen.
