A 7,8-dihydro- [1H or 2H] -imidazo [1,2-a] pyrazolo [4,3-e] pyrimidin-4 (5H) -one or 7,8,9-trihydro- [1H or 2H ] -pyrrhido [1,2- a] pyrazolo [4,3-e] pyrimidin-4 (5H) -one, substituted in positions 1 or 2 with C2-9 alkyl, C3-9 cycloalkyl, heteroarylalkyl or arylalkyl in form free or salt, wherein: alkyl is a saturated or unsaturated hydrocarbon residue, which may be linear or branched and may be optionally substituted with halogen, hydroxy or carboxy； cycloalkyl is a saturated or unsaturated non-aromatic hydrocarbon moiety, whose at least some carbon atoms form a monocyclic or bicyclic, or bridged cyclic non-aromatic structure, and which may be optionally substituted with halogen, hydroxy or carboxy； aryl is a monocyclic or bicyclic aromatic hydrocarbon, optionally substituted with alkyl, halogen, haloalkyl, hydroxy, carboxy, or an additional aryl or heteroaryl； and heteroaryl is an aromatic moiety in which one or more of the atoms constituting the aromatic ring is sulfur or nitrogen instead of carbon, which may be optionally substituted with alkyl, halogen, haloalkyl, hydroxy or carboxy； with the proviso that said arylalkyl is substituted with alkyl, halogen, haloalkyl, hydroxy, carboxy, or an additional aryl or heteroaryl.Una 7,8-dihidro-[1H o 2H]-imidazo[1,2-a]pirazolo[4,3-e]pirimidin-4(5H)-ona o 7,8,9-trihidro-[1H o 2H]-pirimido[1,2- a]pirazolo[4,3-e]pirimidin-4(5H)-ona, sustituida en las posiciones 1 o 2 con alquilo C2-9, cicloalquilo C3-9, heteroarilalquilo o arilalquilo en forma libre o de sal, en donde: alquilo es un resto de hidrocarburo saturado o insaturado, que puede ser lineal o ramificado y que puede estar opcionalmente sustituido con halógeno, hidroxi o carboxi； cicloalquilo es un resto de hidrocarburo no aromático saturado o insaturado, cuyos al menos algunos átomos de carbono forman una estructura no aromática monocíclica o bicíclica, o cíclica puenteada, y que puede estar opcionalmente sustituida con halógeno, hidroxi o carboxi； arilo es un hidrocar
