Disclosed are compounds of formula (I), pharmaceutical compositions comprising such compounds and methods/uses of using the same, for example, for treating a JAK-related disorder, such as cancer, cancer cachexia or an immune disorder: (I) wherein R1 is methyl or ethyl； R2 is selected from methyl, ethyl, methoxy and ethoxy； R3 is selected from hydrogen, chlorine, fluorine, bromine and methyl； R4 is selected from methyl, ethyl and -CH2OCH3； R5 and R6 are each individually methyl or hydrogen； and R7 is selected from methyl, ethyl, -(CH2)2OH and –(CH2)2OCH3, or a pharmaceutically acceptable salt thereof.
