Disclosed are compounds of formula (I), pharmaceutical compositions comprising such compounds and methods/uses of using the same, for example, for treating a JAK-related disorder, such as cancer, cancer cachexia or an immune disorder: wherein R1 is methyl or ethyl； R2 is selected from methyl, ethyl, methoxy and ethoxy； R3 is selected from hydrogen, chlorine, fluorine, bromine and methyl； R4 is selected from methyl, ethyl and -CH2OCH3； R5 and R6 are each individually methyl or hydrogen； and R7 is selected from methyl, ethyl, -(CH2)2OH and -(CH2)2OCH3, or a pharmaceutically acceptable salt thereof.揭露的是具有式(I)之化合物，包括此類化合物之醫藥組成物，以及使用此類化合物用於，例如治療JAK相關的障礙之方法/用途，該障礙係例如，癌症、癌症惡病質或免疫障礙：其中R1係甲基或乙基；R2係選自甲基、乙基、甲氧基和乙氧基；R3係選自氫、氯、氟、溴和甲基；R4係選自甲基、乙基和-CH2OCH3；R5和R6各自獨立地是甲基或氫；並且R7係選自甲基、乙基、-(CH2)2OH和-(CH2)2OCH3，或其藥學上可接受的鹽。
