María Georgina HOTTER CORRIPIO,Ana Maria SOLA MARTÍNEZ,Jorge Vicente MARTÍN CORDERO,Pablo GARCÍA DE LA RIVA MESTRE,Rubén DOMÍNGUEZ SÁNCHEZ,Jaime SÁNCHEZ MORENO,Xavier GINESTA BUCH,Anna RODRÌGUEZ GARCI
申请号：
US15715036
公开号：
US20180087031A1
申请日:
2017.09.25
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention provides an in vitro method for inducing macrophage polarization to an M2 phenotype useful for tissue repair. The method described in the present invention comprises the in vitro exposure of macrophages to repeated series of hypoxia-reoxygenation. Activated M2 macrophages obtained by this method overexpress molecules important for tissue remodeling and amelioration of inflammation, such as NGAL and anti-inflammatory cytokines (IL-10). Thus, M2 macrophages obtained by this method are useful as cell therapy for tissue regeneration. The invention also provides pharmaceutical compositions and kits comprising the M2 macrophages obtained by the described method. The invention further refers to a device for inducing hypoxia and re-oxygenation conditions on isolated macrophages according to the described method.
