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IMPLANT A POROSITE CONTROLEE EN UN MATERIAU HYBRIDE
专利权人:
UNIVERSITE BLAISE PASCAL-CLERMONT-FERRAND II
发明人:
LAO, JONATHAN, CLAUDE, ALEXANDRE,LAO, Jonathan, Claude, Alexandre,LACROIX, JOSÉPHINE,LACROIX, Joséphine,JALLOT, EDOUARD, DANIEL, ALBERT,JALLOT, Edouard, Daniel, Albert,DIEUDONNE, XAVIER,DIEUDONNE, Xav
申请号:
IBIB2014/061914
公开号:
WO2014/195863A1
申请日:
2014.06.03
申请国别(地区):
WO
年份:
2014
代理人:
摘要:
The invention relates to an implant material for filling bone defects, for bone regeneration and for bone tissue engineering, to an implant comprising this material, to a method for producing such an implant, and to a method for producing a hybrid material. The implant material of the invention comprises a hybrid material comprising: a bioactive glass M based on SiO2 and CaO, optionally containing P2O5 and/or optionally doped with strontium, and a biodegradable polymer P soluble in a solvent and chosen from among the bioresorbable polysaccharides, preferably chosen from among dextran, hyaluronic acid, agar, chitosan, alginic acid, sodium or potassium alginate, galactomannan, carrageenan, pectin the bioresorbable polyesters, preferably polyvinyl alcohol, polylactic acid or the biodegradable synthetic polymers, preferably a polyethylene glycol or polycaprolactone and proteins, preferably gelatin or collagen, and it consists of a matrix comprising at least the biodegradable polymer P, this matrix having pores having the shape of spheres or polyhedrons inscribed within a sphere, the diameter of the spheres being between 100 and 900 μm inclusive, with a deviation between the diameter of the smallest sphere and the largest being at most 70% with respect to the arithmetic mean diameter of all the spheres of the implant, and the interconnections between the pores having their smallest dimension at between 25 μm and 250 μm inclusive, at least 70% by number of pores having at least one interconnection with another pore. The invention has an application in the medical field in particular.Linvention concerne un matériau dimplant pour le comblement de défauts osseux, la régénération osseuse et lingénierie tissulaire de los, un implant comprenant ce matériau, un procédé de fabrication dun tel implant ainsi quun procédé de fabrication dun matériau hybride. Le matériau dimplant de linvention comprend un matériau hybride comprenant : un verre bioactif M à base de SiO2 et CaO, option
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