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IMPLANT A POROSITE CONTROLEE COMPRENANT UNE MATRICE REVETUE DUN VERRE BIOACTIF OU DUN MATERIAU HYBRIDE
专利权人:
UNIVERSITE BLAISE PASCAL-CLERMONT-FERRAND II
发明人:
LAO, JONATHAN, CLAUDE, ALEXANDRE,LAO, Jonathan, Claude, Alexandre,LACROIX, JOSÉPHINE,LACROIX, Joséphine,JALLOT, EDOUARD, DANIEL, ALBERT,JALLOT, Edouard, Daniel, Albert,DIEUDONNE, XAVIER,DIEUDONNE, Xav
申请号:
IBIB2014/061915
公开号:
WO2014/195864A1
申请日:
2014.06.03
申请国别(地区):
WO
年份:
2014
代理人:
摘要:
The invention relates to an implant material for filling bone defects, for bone regeneration and for bone tissue engineering, to an implant comprising this material, and to a method for producing such an implant. The implant material of the invention comprises: a bioactive glass M based on SiO2 and CaO, optionally containing P2O5 and/or optionally doped with strontium, and a biodegradable polymer P soluble in at least one solvent S1 and chosen from among the bioresorbable polysaccharides, preferably chosen from among dextran, hyaluronic acid, agar, chitosan, alginic acid, sodium or potassium alginate, galactomannan, carrageenan, pectin the bioresorbable polyesters, preferably polyvinyl alcohol or polylactic acid the biodegradable synthetic polymers, preferably a polyethylene glycol or polycaprolactone and proteins, preferably gelatin or collagen, and it consists of a matrix comprising at least the biodegradable polymer P, this matrix being covered by the bioactive glass M or by a hybrid material H formed by a biodegradable polymer identical to or different from the biodegradable polymer P and the bioactive glass M, this matrix having at least 70% by number of pores having at least one interconnection with another pore, and the shape of spheres or polyhedrons inscribed within a sphere, the diameter of the spheres being between 100 and 900 μm inclusive, with a deviation between the diameter of the smallest sphere and the largest being at most 70% with respect to the arithmetic mean diameter of all the spheres of the implant, and the interconnections between the pores having their smallest dimension between 25 μm and 250 μm inclusive. The invention has an application in the medical field in particular.Linvention concerne un matériau dimplant pour le comblement de défauts osseux, la régénération osseuse et lingénierie tissulaire de los, un implant comprenant ce matériau et un procédé de fabrication dun tel implant. Le matériau dimplant de linvention comprend : un verre
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中国工程科技知识中心
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