Yoshiro Niitsu,Victor Knopov,Joseph E. Payne,Zheng Hou,John A. Gaudette,Violetta Akopian,Richard P. Witte,Mohammad Ahmadian,Loren A. Perelman,Yasunobu Tanaka,Priya Karmali,Sridhar C. Nagarajan
申请号：
US15919098
公开号：
US20180208547A1
申请日:
2018.03.12
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Here described is a method of delivery of a drug to a stellate cell using a composition comprising a compound of formula I:wherein R1 and R2 are independently selected from C10 to C18 alkyl, C12 to C18 alkenyl, and oleoyl； R3 and R4 are independently selected from C1 to C6 alkyl and C2 to C6 alkanol； X is selected from —CH2—, —S—, and —O—, or X is absent； Y is selected from —(CH2)n, —S(CH2)n—, —O(CH2)n—, -thiophene-, -SO2(CH2)n—, and ester； n=1-4； a=1-4； b=1-4； c=1-4； and Z− is a counterion.
