4-Carboxamide-isoindolinone derivatives as selective PARP-1 inhibitors

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专利权人:

ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ

发明人:

パペオ，ジャンルカ・マリアーノ・エンリコ,クラサビン，ミハイル・ユリエビッチ,オルシーニ，パオロ,スコラロ，アレッサンドラ,パペオ,ジャンルカ・マリアーノ・エンリコ,クラサビン,ミハイル・ユリエビッチ,オルシーニ,パオロ,スコラロ,アレッサンドラ

申请号：

JP2015538431

公开号：

JP6314147B2

申请日:

2013.10.23

申请国别(地区):

JP

年份:

2018

代理人:

摘要：

There are provided substituted 4-carboxamido-isoindolinone derivatives which selectively inhibit the activity of poly (ADP-ribose) polymerase PARP-I with respect to poly (ADP-ribose) polymerase P ARP-2. The compounds of this invention are therefore useful in treating diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of in-flammation. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.

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