4-CARBOXAMIDO-ISOINDOLINONE DERIVATIVES AS SELECTIVE PARP-1 INHIBITORS

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专利权人:

NERVIANO MEDICAL SCIENCES S.R.L.

发明人:

Gianluca Mariano Enrico Papeo,Mikhail Yurievitch Krasavin,Paolo Orsini,Alessandra Scolaro

申请号：

US14438410

公开号：

US20150274662A1

申请日:

2013.10.23

申请国别(地区):

US

年份:

2015

代理人:

摘要：

There are provided substituted 4-carboxamido-isoindolinone derivatives which selectively inhibit the activity of poly (ADP-ribose) polymerase PARP-1 with respect to poly (ADP-ribose) polymerase PARP-2. The compounds of this invention are therefore useful in treating diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.

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