A guide tube for tattoo machine needles has a through hole slidingly engaged, in use, by a rod, which carries the needles the tube has at least one slot, which is transversal to the axis of the hole to reach beyond said longitudinal axis in use, an elastic band is provided in the slot to come in contact against a zone of the rod and radially force the rod and/or the needles against a surface of the hole close to the outlet of the hole.