BREITENBACH ARMIN,ARMIN BREITENBACH,HANS MICHAEL-WOLFF,MICHAEL-WOLFF HANS
申请号：
PL374852
公开号：
PL221308B1
申请日:
2003.07.29
申请国别(地区):
PL
年份:
2016
代理人:
摘要：
In a transdermal therapeutic system (TTS) comprising an adhesive matrix containing rotigotine (A) as active agent, the matrix is a hot-meltable contact adhesive. Independent claims are included for: (1) a TTS for continuous delivery of (A), which induces an average plasma (A) concentration of 0.4-2 ng/ml over a period of at least 5 days on application to human skin or transports (A) through the skin at a steady-state flux rate of 200-300 mu g/h over a period of at least 5 days； and (2) the production of a TTS including an adhesive matrix containing (A), by melting and homogenizing the components of the matrix at 70-200 (preferably 120-180)[deg]C (preferably in an extruder) before lamination. ACTIVITY : Antiparkinsonian； Muscular-Gen. MECHANISM OF ACTION : Dopamine agonist.
