The invention relates to 7-alkynyl-1,8-naphthyridone derivatives of formula (I):in which R1,R2,R3and R4are as defined in the description. Process for the preparation thereof and therapeutic use thereof.本發明係關於式(I)之7-炔基-1,8-萘啶酮衍生物:其中R1、R2、R3及R4係如說明書中所定義。其製備方法及其治療用途。