您的位置: 首页 > 农业专利 > 详情页

Aminostatin derivatives for the treatment of osteoarthritis
专利权人:
Merck Patent GmbH
发明人:
KLEIN, Markus,TSAKLAKIDIS, Christos,GUEHRING, Hans,LEUTHNER, Birgitta
申请号:
ES12700091
公开号:
ES2649964T3
申请日:
2012.01.09
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
Compounds of the formula I ** Formula ** in which I1, I2, I3, I4, I5 are independently from each other N or CR ', T is an unsubstituted or substituted phenyl or naphthyl once, twice, three or four times with R, or a saturated, unsaturated or aromatic one or two cycle heterocycle with 1 to 4 atoms of N, O and / or S that may be substituted once, twice or three times with R,>; = S,>; = NR 'and / o>; = O, R 1 is ethyl, n-propyl, iso-propyl, cyclopropyl, butyl, iso-butyl, sec-butyl, cyclobutyl, tert-butyl, phenyl, benzyl, 2-oxetanyl, 3-oxetanyl, tetrahydro- furan-3-yl, tetrahydro-furan-2-yl, cyclopentyl, pentyl, methylsulfanylmethyl, ethylsulfanylmethyl, 2-methylsulfanylethyl or 1-methylsulfanylethyl, A1 represents from 0 to 4 peptide-type amino acid residues linked together selected from the group consisting of alanine, glycine, cyclopropylglycine, cyclobutylglycine, cyclopentylglycine, cyclohexylglycine, 3-oxetanylglycine, 3-oxetanylglycine, tetrahydro-furan-3-ylglycine, tetrahydro-furan- 2- ilglycine, ethylsulfanylmethylglycine, 2-methylsulfanylethylglycine, 1-methylsulfanylethylglycine, valine, norvaline, aminobutyric acid, leucine, isoleucine, proline, tert-leucine, norleucine, methionine, phenylalanine, naphthylalanine-O-seryl-methyl-ethyl-serine , -OCO-, -NRCO-, -SO2- and -NRSO2- and A2 represents 0 to 4 peptide-type amino acid residues linked together selected from the group consisting of alanine, glycine, cyclopropylglycine, cyclobutylglycine, cyclopentylglycine, cyclohexylglycine, 3 -oxetanylglycine, 3-oxetanylglycine, tetrahydro-furan-3-ylglycine, tetrahydro-furan-2-ylglycine, ethylsulfanylmethylglycine, 2-methylsulfanylethylglycine, 1-methylsulfanylethylglycine, valine, norvaline, leucinezine, leuccinazine, leuccinazine, leuccinazine, leuccinazine, leuccinazine, leuccinazine, leuccinazine, leuccinazine, leuccinazine, leuccinazine, leuccinazine, leuccinazine, leuccinazine, leuccinazine, leuccinazine, leuccinazine, leuccinazine norleucine, methionine, ph
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充