PRO-INFLAMMATORY AND ADJUVANT FUNCTIONS OF TOLL-LIKE RECEPTOR 4 ANTAGONISTS

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专利权人:

发明人:

申请号：

EP16737709.2

公开号：

EP3244923A2

申请日:

2016.01.12

申请国别(地区):

EP

年份:

2017

代理人:

摘要：

The present invention provides methods and compositions for specific activation of inflammatory responses in dendritic cells (DCs). 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (PAPC) and its oxidized variant (oxPAPC) were identified to promote DC-mediated immunity, and are provided as adjuvants in immunostimulatory compositions, including vaccines.

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