MATERIAUX ET METHODES POUR LE TRAITEMENT DE LA FIBROSE KYSTIQUE ET DE L'INDUCTION DE LA SECRETION D'IONS

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专利权人:

UNIVERSITY OF FLORIDA RESEARCH FOUNDATION; INC.

发明人:

VIDYASAGAR, SADASIVAN,OKUNIEFF, PAUL,PRABHAKARAN, SREEKALA,ZHANG, LURONG

申请号：

CA2869430

公开号：

CA2869430A1

申请日:

2013.03.15

申请国别(地区):

CA

年份:

2013

代理人:

摘要：

The present invention provides materials and methods for inducing ion secretion and/or for treating cystic fibrosis. In one embodiment, the composition comprises glucose and/or a non-metabolizable glucose analog and/or non-structural protein (NSP4), a NSP4 peptide, or a NSP4 toxoid as the active ingredient, formulated with pharmaceutically - acceptable carriers. In a preferred embodiment, the composition is in a form of an aerosol preparation for intranasal and/or pulmonary administration, and is used to stimulate chloride and fluid secretion in nasal, tracheal and/or bronchial epithelium.

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