Materials and methods for treatment of cystic fibrosis and for induction of ion secretion

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专利权人:

University of Florida Research Foundation; Incorporated

发明人:

Sadasivan Vidyasagar,Paul Okunieff,Sreekala Prabhakaran,Lurong Zhang

申请号：

US14390301

公开号：

US10086007B2

申请日:

2013.03.15

申请国别(地区):

US

年份:

2018

代理人:

摘要：

The present invention provides materials and methods for inducing ion secretion and/or for treating cystic fibrosis. In one embodiment, the composition comprises glucose and/or a non-metabolizable glucose analog and/or non-structural protein (NSP4), a NSP4 peptide, or a NSP4 toxoid as the active ingredient, formulated with pharmaceutically-acceptable carriers. In a preferred embodiment, the composition is in a form of an aerosol preparation for intranasal and/or pulmonary administration, and is used to stimulate chloride and fluid secretion in nasal, tracheal and/or bronchial epithelium.

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