The present invention relates to a kind of grumeleuses of the extracorporeal blood circuit of detection device based on pressure. The device includes that the liquid of at least one circulate operation pump pumping is located at extracorporeal circuit and at least one pressure sensor, these settings, so that it is determined that the curve of current time is in pumping, pass through the electric current pump circulation of pump, wherein device attacks at least one storage equipment, wherein at least a reference pressure curve was stored in based at least one pressure curve with the time, if it is the pump for determining the electric current pump circulation before pump circulation pump, device includes at least one analytical unit, one kind is designed to compare current curves, has the corresponding time mode of reference pressure curve.