TITBALL, RICHARD W.,BOKORI-BROWN, MONIKA,NAYLOR, CLAIRE
申请号：
CA2868057
公开号：
CA2868057A1
申请日:
2013.03.28
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
There is provided an epsilon toxin epitope polypeptide comprising a sequence of at least 10 contiguous amino acids from SEQ ID NO:3, the sequence comprising a mutation of at least one tyrosine residue compared to the equivalent sequence in SEQ ID NO:3, the polypeptide being capable of binding an antibody which binds to SEQ ID NO:5 and having reduced toxicity compared with the toxicity of SEQ ID NO:5. The polypeptide is useful in a method of vaccinating a subject against developing a disease caused by Clostridium perfringens and/or caused by (or associated with the presence of) active epsilon toxin.
