An image pickup device includes a plurality of pixels, a pixel signal processing circuit, a reference signal generation circuit, a level shift circuit, and a signal output terminal. The pixel signal processing circuit outputs an image pickup signal based on pixel signals. The level shift circuit shifts a first level of the image pickup signal in a direction in which the first level is moved away from a second level of a reference signal, or shifts the second level in a direction in which the second level is moved away from the first level. The signal output terminal outputs to an image pickup signal processing circuit the reference signal and the image pickup signal the first level of which has been shifted, or the reference signal the second level of which has been shifted and the image pickup signal. The image pickup signal processing circuit calculates the difference between the reference signal and the image pickup signal that are output from the signal output terminal.
