Thomas P Zimmerman,Valery Novokhatny,Shan Jiang,James D Colandene
申请号：
US13761684
公开号：
US09879246B2
申请日:
2013.02.07
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention provides a fibrinolytic composition useful as a therapeutic for administration to a patient having a thrombotic occlusion. In one aspect of the present invention, the fibrinolytic composition comprises a reversibly inactivated acidified serine protease substantially free of a plasminogen activator, a low buffering capacity buffer, and optionally, a stabilizing agent. In another aspect of the invention, the fibrinolytic composition of the present invention comprises a reversibly inactivated acidified plasmin substantially free of a plasminogen activator, a low buffering capacity buffer, and optionally, a stabilizing agent.
