THROMBOLYSIS METHOD THROUGH LOCAL TREATMENT WITH REVERSIBLE INACTIVATED, ACIDIFIED PLASMINE

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专利权人:

Grifols Therapeutics Inc.

发明人:

Valery NOVOKHATNY,Gary JESMOK,Kyle LANDSKRONER,Kathryn TAYLOR,Thomas ZIMMERMAN

申请号：

DE60036017

公开号：

DE60036017T3

申请日:

2000.11.13

申请国别(地区):

DE

年份:

2017

代理人:

摘要：

The present invention provides a fibrinolytic composition useful as a therapeutic for administration to a patient having a thrombotic occlusion. In one aspect of the present invention, the fibrinolytic composition comprises a reversibly inactivated acidified serine protease substantially free of a plasminogen activator, a low buffering capacity buffer, and optionally, a stabilizing agent. In another aspect of the invention, the fibrinolytic composition of the present invention comprises a reversibly inactivated acidified plasmin substantially free of a plasminogen activator, a low buffering capacity buffer, and optionally, a stabilizing agent.

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