Richard W. Compans,Sang-Moo Kang,Jadranka Bozja,Bao-Zhong Wang,Jae-Min Song
申请号：
US13084367
公开号：
US20120052082A1
申请日:
2011.04.11
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A cross-protective influenza virus vaccine has been designed based on the incorporation of the genetically engineered, highly conserved M2 influenza viral protein optionally in combination with an adjuvant such as a bacterial flagellin protein incorporated into the membrane of a virosome or virus-like particles. Immunogenicity and the breadth of cross protection efficacy are significantly enhanced using multiple copies of the influenza M2 protein as a membrane bound tetramer and/or in combination with a membrane bound adjuvant. A method for vaccinating a subject for influenza A has also been developed that results in broad and improved cross-protection against multiple subtypes of influenza A virus.
