AMBERG, WILHELM,OCHSE, MICHAEL,LANGE, UDO,KLING, ANDREAS,BEHL, BERTHOLD,HORNBERGER, WILFRIED,MEZLER, MARIO,HUTCHINS, CHARLES
申请号：
PE0014962011
公开号：
PE00622012A1
申请日:
2010.02.16
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Aminotetralina refers to compounds of formula (i) where a is a Ring of 5 or 6 members R is R1 - W - Q - and - A1 - A2 - X1, where R1 is H, alkyl (C1 - C6), hidroxialquilo (c1-c4), aminoalquilo (C1 - C4), among others W is nr8 or a Union, where R8 is H or alkyl (C1 - C6) A1 is alquileno (C1 - C4) Or a Union Q is s (OR) 2 or C (OR) and NR9 or a Union, where R0 is H, alkyl (C1 - C6)(C3 - C12 cycloalkyl), among others A2 is alquileno (c1-c4), alquenileno (c2-c4), among others x1 is o, S, alquileno (c1-c4), among others R2 is H, halogen, alkyl (C1 - C6), among others R3 is H, halogen, alkoxy (C1 - C6), among others R4A is H, ch2cn, Cho, among others r4b is H, alkyl, Amine (C1 - C6), and Among others x2 is a Union, or s, among others X3 is a Union or, S,Among others, R5 is aryl (C6, C12 cycloalkyl) (C3 - C12), among others n is 0 to 2. Preferred compounds are: N - (2 - (7 - amino - 4 - (3,4 - diclorobencil 5,6,7,8) - - 2 - - tetrahidronaftalen iloxi) ethyl) - 1H imidazole - 1 - methyl - 4 - sulfonamide {2 - [7 - amino - 4 - (3,4 - Dichloro benzyl) - minutebug - tetrahydro - naftalen - 2 - iloxi] ethyl} - 1 - methyl - Acid amide 1h pyrazole - 4 - sulfonic acid among others.It also relates to a Pharmaceutical composition. These compounds are inhibitors of the Glycine Transporter GlyT1 being useful in the treatment of Dementia, Schizophrenia, Anxiety DisorderSE REFIERE A COMPUESTOS DERIVADOS DE AMINOTETRALINA DE FORMULA (I) DONDE A ES UN ANILLO DE 5 O 6 MIEMBROS R ES R1-W-A1-Q-Y-A2-X1-, EN DONDE R1 ES H, ALQUILO(C1-C6), HIDROXIALQUILO(C1-C4), AMINOALQUILO(C1-C4), ENTRE OTROS W ES NR8 O UNA UNION, DONDE R8 ES H O ALQUILO(C1-C6) A1 ES ALQUILENO(C1-C4) O UNA UNION Q ES S(O)2 O C(O) Y ES NR9 O UNA UNION, DONDE R9 ES H, ALQUILO(C1-C6), CICLOALQUILO(C3-C12), ENTRE OTROS A2 ES ALQUILENO(C1-C4), ALQUENILENO(C2-C4), ENTRE OTROS X1 ES O, S, ALQUILENO(C1-C4), ENTRE OTROS R2 ES H, HALOGENO, ALQUILO(C1-C6), ENTRE OTROS R3 ES H, HALOGENO, ALCOXI(C1-C6), ENTRE OTROS R4a ES H, CH2CN, CHO, E
