HAWKINS, Lynn,BOIVIN, Roch,HANSEN, Hans,ISHIZAKA, Sally,MACKEY, Matthew,SCHILLER, Shawn,OGAWA, Chikako,NARAYAN, Sridhar,BERGER, Gregory,ENDO, Atsushi,YU, Robert T.
申请号：
ES14790936
公开号：
ES2670550T3
申请日:
2014.10.14
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of formula (I) or a pharmaceutically acceptable salt thereof: ** Formula ** where R 8 is H or methyl； R9 is -H, methyl or hydroxyl； R10 is methyl, hydroxyl or NR11R12； and where R11 and R12 are independently selected, and where R11 is -H, methyl or -CH2-C (O) CH2CH3； and R12 is -H, oxopyrrolidinyl, dioxidothiopyranyl, isopropylsulfonyl, tetrahydropyranyl, oxetanyl, tetrahydrofuranyl, hydroxy, dimethylaminoethanesulfonyl, aminoethanesulfonyl, dimethylaminopropanesulfonyl, C1-C6 linear alkyl, branched or cyclic, optionally methoxy, methoxy, methoxy, methyl , oxo-, methyl imidazolyl, methylthio piperazinyl optionally substituted with methyl or -CF3, acetamidyl optionally substituted with methyl or ethyl, oxazolyl optionally substituted with methyl, pyrazolyl optionally substituted with methyl, cyano or hydroxyl, -C (O) R13, where R13 it is C1 to C7 cyclic, branched or linear alkyl, optionally substituted with NR15R14, where R15 and R14 are independently selected from methyl and -H； methoxy, hydroxy, methylthio, ethylthio, methylsulfonyl, oxo-, thiazolidinyl, pyridinyl, pyrazolopyridinyl, methylamino, thiazolyl, -F, morpholinyl, methylisoxazolyl, methylxetanyl, aminooxetanyl, phenyl optionally substituted with hydroxyl, NH2； a five-element cycloalkyl, saturated or unsaturated, in which 1 or 2 carbon atoms are replaced by nitrogen atoms, where the cycloamine or cyclodiamine is optionally substituted with hydroxyl or methyl.Un compuesto de fórmula (I) o una sal farmacéuticamente aceptable de éste:**Fórmula** donde R8 es H o metilo； R9 es -H, metilo o hidroxilo； R10 es metilo, hidroxilo o NR11R12； y donde R11 y R12 se eligen independientemente, y donde R11 es -H, metilo o -CH2-C(O)CH2CH3； y R12 es -H, oxopirrolidinilo, dioxidotiopiranilo, isopropilsulfonilo, tetrahidropiranilo, oxetanilo, tetrahidrofuranilo, hidroxilo, dimetilaminoetanosulfonilo, aminoetanosulfonilo, dimetilaminopropanosulfonilo,C1-C6 alquilo lineal, ramificado o cíclico, opcionalmente sustituid
