Disclosed is a motilin derivative compound comprising the sequence represented by the following general formula 1: X1 Val X2 lIe Phe Thr Tyr Gly X3 Leu GIn Arg X4 GIn Glu Lys Glu Arg X5 Lys Pro Gln (XVXIFTYGXLQRXQEKERXKPQ). Further disclosed are compounds which is depicted by the sequence selected from the group consisting of SEQ ID NOS: 3 to 15 or a pharmaceutically acceptable salt thereof. alpha