KORTYLEWSKI, MARCIN TOMASZ,SWIDERSKI, PIOTR MAREK,MOREIRA, DAYSON FRIACA
申请号:
CA2991052
公开号:
CA2991052A1
申请日:
2016.06.30
申请国别(地区):
CA
年份:
2017
代理人:
摘要:
The present disclosure relates to an isolated compound including a phosphorothioated oligodeoxynucleotide (ODN) sequence conjugated to a short-activating RNA (saRNA) or an antisense oligonucleotide sequence (ASO), compositions of such a compound, and method of treatment of cancer and autoimmune diseases (with or without stimulating immune response), method of immune stimulation, method of activating CEBPA, and method of reducing activity of STAT transcription factor, by one of the disclosed compounds or compositions.