compound, medicament, pharmaceutical composition, combined pharmaceutical preparation, uses of a compound and a combined preparation, and process for the preparation of compound.
AXEL STOIT,CORNELIS G. KRUSE,LECHOSLAW A. TURSKI,MARTINUS TH. M. TULP,SANDER VADER
申请号：
BRPI0813658
公开号：
BRPI0813658A2
申请日:
2008.06.23
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
The invention concerns venlafexine-N-oxide and O-desmethylvenlafaxine-N-oxide as prodrugs of venlafexine and its major (active) metabolite O-desmethylvenlafaxine respectively, to pharmaceutical compositions containing these N-oxides, to methods for preparing them, and methods for preparing compositions. The invention relates to N-oxide, having formula (1), wherein R<；SP>；1<；/SP>； is H or CH3, and tautomers, stereoisomers, hydrates and solvates thereof. The invention also relates to the uses of the N-oxides and compositions, particularly for the manufacture of medicaments useful in the treatment of affections or diseases effectively treatable-albeit with side effects- with venlafexine.
