Janssen Vaccines &； Prevention B.V.;Massachusetts Institute of Technology
发明人:
Ronald VOGELS,Marijn VAN DER NEUT KOLFSCHOTEN,Darrell J. IRVINE,Ron WEISS,Ely Blanton PORTER,Mariane Bandeira MELO,Tasuku KITADA
申请号：
US16634205
公开号：
US20200230225A1
申请日:
2018.07.27
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Compositions and methods are described for inducing an immune response against an immunogen in humans. The induced immune response is obtained by administering a heterologous prime-boost combination of an in vitro transcribed (IVT) self-replicating RNA (repRNA) and an adenovirus vector. The compositions and methods can be used to provide a protective immunity against a disease, such as a viral infection or a cancer, in humans.
