Felix Meiser;Marck Norret;H. William Bosch;Matthew Callahan;Adrian Russell
发明人:
H. William Bosch,Matthew Callahan,Felix Meiser,Marck Norret,Adrian Russell
申请号:
US13781115
公开号:
US10022303B2
申请日:
2013.02.28
申请国别(地区):
US
年份:
2018
代理人:
摘要:
Methods for making inhalable composite particles comprising a pharmaceutically-active agent, the method comprising: a) providing composite particles comprising a millable grinding matrix and a solid pharmaceutically-active agent, wherein the pharmaceutically-active agent has an median particle size on a volume average basis between 50 nm and 3 μm; and b) milling the composite particles in a mill without milling bodies for a time period sufficient to produce inhalable composite particles having a mass median aerodynamic diameter between 1 μm and 20 μm are described.