BOSCH, H. WILLIAM,CALLAHAN, MATTHEW,MEISER, FELIX,NORRET, MARCK,RUSSELL, ADRIAN
申请号：
SG11201405243T
公开号：
SG11201405243TA
申请日:
2013.02.28
申请国别(地区):
SG
年份:
2014
代理人:
摘要：
Methods for making inhalable composite particles comprising a pharmaceutically-active agent, the method comprising: a) providing composite particles comprising a millable grinding matrix and a solid pharmaceutically-active agent, wherein the pharmaceutically-active agent has an median particle size on a volume average basis between 50 nm and 3 μm； and b) milling the composite particles in a mill without milling bodies for a time period sufficient to produce inhalable composite particles having a mass median aerodynamic diameter between 1 μm and 20 μm are described.
