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BIOMARKER FOR CORONARY ARTERY DISEASE
专利权人:
Board of Regents of the University of Nebraska
发明人:
Geoffrey M. THIELE,Daniel R. ANDERSON,Michael J. DURYEE
申请号:
US15900680
公开号:
US20180313826A1
申请日:
2018.02.20
申请国别(地区):
US
年份:
2018
代理人:
摘要:
In various embodiments methods are provided for identifying a mammal having an elevated risk for an adverse cardiac event (e.g. an MI) and/or determining the prognosis for the mammal. In certain embodiments the methods comprise determining, or causing to be determined, the presence and/or level of antibodies that bind a malondialdehyde-acetaldheyde adduct (MAA adduct) in a biological sample from the mammal, where an elevated level of anti-MAA adduct antibodies, as compared to the level found in a normal healthy mammal is an indicator that that said mammal has one or more atherosclerotic lesions and/or is at elevated risk for a myocardial infarction.
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