Compounds derived from aminofosfonatos or aminofosfatos Diphenyl sulfide, 4000 mAh Receptor Antagonists； Drug farmceutica and composition that is useful for the Treatment or prevention of bronchial Asthma, COPD, Solid Tumors, glaucoma and arteriosclerosis, thrombosis, sepsis, entr And other diseases.
ISHIKAWA, KUMI,KOGA, SHIGERU,KOHNO, YASUHI,FUJII, KIYOSHI,YOSHIKAWA, KEN
申请号：
CL2013001329
公开号：
CL2013001329A1
申请日:
2013.05.14
申请国别(地区):
CL
年份:
2014
代理人:
摘要：
[Problem] To provide a diphenyl sulfide derivative which is useful as a pharmaceutical product that has excellent S1P3 antagonist activity. [Solution] The inventors have discovered that a diphenyl sulfide derivative represented by general formula (1) (wherein R1 represents an alkoxy group having 1-6 carbon atoms, R2 represents a propyl group or an allyl group, X represents methylene or an oxygen atom, and Z represents a halogen atom) has excellent S1P3 antagonist activity as a result of extensive researches for the production of a compound that has S1P3 antagonist activity.COMPUESTOS DERIVADOS DE AMINOFOSFONATOS O AMINOFOSFATOS DE SULFURO DE DIFENILO, ANTAGONISTAS DEL RECEPTOR S1P3； MEDICAMENTO Y COMPOSICION FARMCEUTICA QUE LOS COMPRENDE, UTIL PARA EL TRATAMIENTO O PREVENCION DE ASMA BRONQUIAL, EPOC, TUMORES SOLIDOS, ARTERIOESCLEROSIS, TROMBOSIS, GLAUCOMA Y SEPSIS, ENTRE OTRAS ENFERMEDADES.
