Formula (1)So the chemical compound which is displayed or the salt which on that medicine is allowed has the PI3 kinase inhibitory action, it is useful chemical compound glenoid riumachi, the clone illness, the hypersensitivity large enteritis, shieguren syndrome, the multiple sclerosis, systemic Characteristic eritomatodesu, the asthma, the atopic Characteristic dermatitis and the artery muscardine, the rejection symptoms, the cancer and the retina symptom to the transplantation internal organs, the dry Ichthyosis, the deformans arthropathy, the age increase macular degeneration, two die diabetes, insulin resistance, obesity, the fatty liver (NAFLD), the non alcoholic Characteristic hepatitis (NASH), or as a preventive medicine or a remedy medicine of the hyperlipemia symptom and the like.式(1)で表される化合物又はその医薬上許容される塩は、PI3キナーゼγ阻害作用を有し、関節リウマチ、クローン病、過敏性大腸炎、シェーグレン症候群、多発性硬化症、全身性エリトマトーデス、喘息、アトピー性皮膚炎、動脈硬化症、移植臓器への拒絶反応、癌、網膜症、乾癬、変形性関節症、加齢黄斑変性症、二型糖尿病、インスリン抵抗性、肥満、脂肪肝(NAFLD)、非アルコール性肝炎(NASH)、又は高脂血症等の予防剤又は治療剤として有用な化合物である。
