WIT, EMMIE DE,卫特 艾米D,衛特 艾米D,SPRONKEN, MONIQUE I. J.,史普洛肯 蒙尼奎I J,史普洛肯 蒙尼奎I J,FOUCHIER, RON A. M.,佛契尔 隆恩A M,佛契爾 隆恩A M,OSTERHAUS, ALBERT D.M.E.,欧斯特豪斯 艾伯特D M E,歐斯特豪斯 艾伯特D M E
申请号：
TW101113590
公开号：
TWI495724B
申请日:
2005.12.23
申请国别(地区):
TW
年份:
2015
代理人:
摘要：
The invention relates to the field of influenza vaccine production. Influenza vaccines have been produced in embryonated hens eggs for over 50 years, but recently there have been considerable efforts to develop cell culture systems for vaccine production. The invention provides a nucleic acid comprising an influenza gene segment and a bacteriophage polymerase promoter or a complementary strand of said nucleic acid, and a cell comprising such a nucleic acid capable of producing desired influenza virus. Furthermore, the invention provides a composition comprising a cell or material derived from a cell according to the invention and a virus or material derived from a viral particle according to the invention.本發明涉及流感疫苗生產領域。流感疫苗已在含胚雞蛋中生產了50多年,但近來對發展用於疫苗生產的細胞培養系統作出了相當多的努力。本發明提供了核酸或所述核酸的互補鏈以及細胞,所述核酸包含流感基因片段和噬菌體聚合酶啟動子,所述細胞包含這樣的能夠產生想要的流感病毒的核酸。此外,本發明提供了組合物,所述組合物包含細胞或來自本發明的細胞的材料以及來源於本發明的病毒顆粒的病毒或材料。
