The present invention provides a use of a composition for preparing a drug for treating alcohol dependence or alcohol abuse in a subject, wherein the composition comprises an effective amount of memantine, wherein the effective amount of memantine is 2-4.7 mg/day.本發明提供一種組合物用於製備一用在一個體中治療酒癮或酒精濫用的藥物之用途,該組合物包含一有效劑量的美金剛(memantine),其中該有效劑量的美金剛為2-4.7mg/天。