The present invention provides an anti-hepatitis C virus E2 protein antibody or antigen-binding antibody fragment thereof having infection inhibiting activity against hepatitis C virus (HCV). The present invention further provides an anti-hepatitis C virus E2 protein antibody or antigen-binding antibody fragment thereof comprising a certain variable region, which have infection inhibiting activity against hepatitis C virus (HCV) and exhibits an escape mutant emergence suppressive property.