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РЕГУЛИРУЕМЫЕ ПРОТЕАЗОЙ АНТИТЕЛА
专利权人:
БАЙЕР ХЕЛСКЕА ЛЛК (US)
发明人:
ВАН Чжочжи (US),ВИНТЕР Рут (US),МЁРФИ Джон (US)
申请号:
RU2014143639
公开号:
RU2014143639A
申请日:
2013.03.14
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. Adjustable protease antibody which specifically binds to tissue factor pathway inhibitor (TFPI), which comprises a variable domain and the constant domain amino acid sequence, join variable domain to the constant domain, wherein the amino acid sequence comprising a cleavage site proteazoy.2. Adjustable protease antibody of claim. 1, where the cleavage site is a protease cleavage site trombinom.3. Adjustable protease antibody of claim. 1, where the cleavage site is a protease cleavage site plazminom.4. Adjustable protease antibody of claim. 1, where the cleavage site is a protease cleavage site of factor Ha.5. Adjustable protease antibody of claim 1 which comprises the amino acid sequence selected from the group consisting of sequences SEQ ID NO:. 131, amino acid sequence 1-239 of SEQ ID NO: 133, SEQ ID NO: 135, the amino acid sequence of SEQ 1-229 ID NO: 136, SEQ ID NO: 139, SEQ ID NO: 140, SEQ ID NO: 143 and SEQ ID NO: 144.6. Adjustable protease antibody according to any one of claims. 1-5, wherein the amino acid sequence further comprises an amino acid linker.7. Adjustable protease antibody according to any one of claims. 1-5, which is a full length antitelom.8. Adjustable protease antibody according to any one of claims. 1-5, which is a fragment antitela.9. A pharmaceutical composition which include adjustable protease antibody according to any one of claims. 1-8 and a pharmaceutically acceptable nositel.10. An isolated nucleic acid molecule encoding a protease adjustable antibody according to any one of claims. 1-8.11. A method of treating coagulopathy which comprises administering to a patient in need thereof a therapeutically effective quant1. Регулируемое протеазой антитело, которое специфически связывается с ингибитором пути тканевого фактора (TFPI), которое включает вариабельный домен, константный домен и аминокислотную последовательность, присоединяющую вариабельный домен к константному домену, где аминокислотная последовательность включает сайт расщепл
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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