Genetically Modified TFPI And Method Of Making The Same

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专利权人:

Huijun Wang;Duan Ma;Jiping Wang;Jingui Mu;Wang Liang

发明人:

Duan Ma,Jingui Mu,Jiping Wang,Huijun Wang,Wang Liang

申请号：

US13297702

公开号：

US20120065135A1

申请日:

2011.11.16

申请国别(地区):

US

年份:

2012

代理人:

摘要：

The present invention provides long half life genetically modified TFPI sequences (LTFPI) for anticoagulation. On the genetically modified TFPI sequence, the lysine at the carboxy-terminal sites 241, 254, 260 and 261 are replaced by alanin and the amino acid asparagine at glycosylation sites 117, 167, 228 and the amino acids serine and threonine at glycosylation sites 174 and 175 are substitutionally mutated. The present invention also provides methods of making the LTFPI through high efficient LTFPI expression from yeast production system.

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中国工程科技知识中心

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http://www.ckcest.cn/home/